The Treaty of Holston was a treaty between the United States government and the Cherokee Nation signed on July 2, 1791 and proclaimed on February 7, 1792. It was signed by William Blount, governor in and over the territory of the United States south of the Ohio River, and superintendent of Indian affairs for the southern district for the United States and various representatives of the Cherokee Nation. The treaty established terms of relations between the United States and Cherokee, and established the Cherokee nation as a protectorate of the United States with the United States managing all foreign affairs of the Cherokee.
A monument of the treaty is located on the banks of the Tennessee River in downtown Knoxville.
